Advantages and Disadvantages of Solid Dose CDMO

 

Various dosage formulations are available based on the administration technique or route. For the diagnosis or treatment of the condition by various methods, solid dosage forms, semi-solid dosage forms, liquid dosage forms, and gaseous dosage forms are utilised. The most important dosage forms in pharmaceuticals are solid ones, which contain one or more doses of the medication. Compared to other dose forms, the solid dosage form is the one that doctors use and recommend the most. Oral administration is possible with it in the form of pills, capsules, powders, etc. The tablet is one of these oral solid dose forms that is utilised the most frequently.

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The Advantages of solid dosage form:

●      The highest accuracy, the least variability, and steady and precise dosing are the main benefits of solid dosage forms.

●      Solid dosage forms are easier to formulate than liquid dosage form.

●      Solid dosage formulations start working quickly.

●      It may be simpler for the sufferer to steer clear of administering several dosages when a number of medications and excipients or components mix.

●      Using a capsule, the medication's liquid dose from the liquid manufacturing CDMO’s form may be changed into its solid counterpart.

●      Various doses are provided based on the patient's needs.

●      These don't need specific storage conditions and are simple to package and transport.

●      It is simple to swallow and can appeal to kids.

●      Water is a pretty simple way to swallow it.

●      When just partial dosages are needed, it is helpful. It can be broken down into components with ease.

●      It doesn't affect the digestive system because it digests quickly and easily.

●      Drugs can be disguised by employing sugar coating for tablets and capsules to cover their disagreeable taste and odour.

●      It may be produced in a variety of bespoke sizes, shapes, and colours.

●      It may shield the API from environmental factors like humidity, temperature, light, etc.

●      The chemical, physical, and microbiological features of solid dosage forms are stable.

Disadvantages of solid dosage form:

●      The primary drawback of the solid dosage CDMO is that it is difficult to ingest, especially for the elderly and young children, and that it cannot be administered to patients who are asleep.

●      They are difficult to make API with slow rates of dissolution, poor water solubility, low density, and high gastrointestinal absorption.

●      When taken as tablets, a number of medications might irritate the stomach.

●      These dose forms are not appropriate for hygroscopic medications.

●      Patients may resist swallowing medications because they taste or smell bad, which causes pain.

●     The pharmaceutical business may see a rise in production costs due to coating, tablet encapsulation, and the intricate capsule manufacturing process.

●      Here are a few illustrations of solid dosage forms.

●     Tablet forms include chewable, buccal, enteric-coated, film-coated, sublingual, effervescent, hard-shelled, soft gelatin, enteric-coated, and HPMC capsules. lozenges, Pastilles, troches, suppositories, powders, and pellets are other tablet dosage forms.

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